Quinic Acids from Aster caucasicus and from Transgenic Callus Expressing a β-Amyrin Synthase§
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چکیده
منابع مشابه
β‐Amyrin synthase from Conyza blinii expressed in Saccharomyces cerevisiae
Conyza blinii H.Lév. is a widely used medicinal herb in southwestern China. The main pharmacological components of C. blinii are a class of oleanane-type pentacyclic triterpene glycosides known as conyzasaponins, which are thought to be synthesized from β-amyrin. However, no genes involved in the conyzasaponin pathway have previously been identified. Here, we identify an oxidosqualene cyclase (...
متن کاملNeuroprotective and neurotrophic effects of quinic acids from Aster scaber in PC12 cells.
Aster scaber T. (Asteraceae) has been used to treat bruises, snakebite, headache, and dizziness in traditional Chinese medicine. In the present study, the neuroprotective effect of four quinic acid derivatives from A. scaber on amyloid Abeta-induced PC12 cell toxicity was investigated. When cells were treated with quinic acid derivatives prior to Abeta, cell toxicity was significantly diminishe...
متن کاملCloning and characterization of a β-amyrin synthase gene from the medicinal tree Aralia elata (Araliaceae).
Aralia elata is an important medicinal plant in China; it produces large amounts of oleanane type triterpene saponins. A full-length cDNA encoding β-amyrin synthase (designated as AeAS) was isolated from young leaves of A. elata by reverse transcription-PCR. The full-length cDNA of AeAS was found to have a 2292-bp open reading frame, encoding a protein with 763 amino acid residues. The ded...
متن کاملProduction of oleanane-type sapogenin in transgenic rice via expression of β-amyrin synthase gene from Panax japonicus C. A. Mey
BACKGROUND Panax japonicus C. A. Mey. is a rare traditional Chinese herbal medicine that uses ginsenosides as its main active ingredient. Rice does not produce ginsenosides because it lacks a key rate-limiting enzyme (β-amyrin synthase, βAS); however, it produces a secondary metabolite, 2,3-oxidosqualene, which is a precursor for ginsenoside biosynthesis. RESULTS In the present study, the P. ...
متن کاملCloning, Characterization and Bacterial Expression of the Β-amyrin Synthase Gene from Panax Japonicus C. A. Mey
Panax japonicus C. A. Mey. is one of the rare traditional Chinese herbal medicines; its main active ingredient is ginsenosides. β-amyrin synthase (βAS) is the rate-limiting enzyme in the biosynthesis pathway of oleanane-type ginsenosides. We cloned for the first time the full-length cDNA of βAS from P. japonicus (GenBank: KP658156) using reverse transcription-polymerase chain reaction (RT-PCR) ...
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2011
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x1100601125